R&D Services: Drug Discovery

Drug Discovery

      The early stages of drug development can be an exciting yet confusing and uncertain time for early stage startups. The transition between research and drug development can be blurred at this stage and while the extreme excitement toward having a drug candidate can be blinding, this is the most important time to place your highest criticism. The sense of urgency and imperative can lead to overlooking some early warning signs on your drug candidate that can snowball into a colossally expensive and time consuming lost if not careful. Three components critical to your success at this stage are 1) understanding the potential safety/efficacy of your compound, 2) assessing the “drug-like” properties of your candidate to gauge you chances of successfully developing a drug to market, and 3) determining the mechanism of action. Constitution Laboratories boost a full service Cancer Biology and molecular pharmacology facility that can help address these components by offering the following services to name a few:

Drug Discovery Services

General R&D

  •  Expertise in cell-based assays to support early-stage drug development
  •  Assay development across a variety of target types and therapeutic areas using a broad range of formats for low to high-throughput applications
  •  Custom Cell and Molecular Biology Research Services

Preclinical Validation of Therapeutic Leads

  •  In vitro efficacy and safety testing:
  • Example Readouts
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    • Cytotoxicity & Cell Proliferation Assays
    • Real-Time Apoptosis/Necrosis Detection
    • Migration/Invasion Assays
    • Transformation Assays
    • Metabolomics

Deconvolution of mode of action

  • Cell Signaling Analysis
  • Molecular and Genetic Analysis
  • Biomarker Validation
  • SAR Investigation

Drug Potential Screening

  • ADME
  • Solubility / preformulation studies
  • In silico assessments. 
biology, research, laboratory
microscope, laboratory, research

Custom Services

In addition, Constitution Laboratories provides special services for oncology drug development including a staff of Ph.D. trained oncology experts and a unique in house authenticated library of over 200 cancer cell lines.

To see more information regarding CL’s Cancer Biology / Molecular Pharmacology Facility, click here.